New anti-aging chemical substances

40% more effective

Who are we looking for?

Our preliminary results confirm biological activity of newly synthesized substances towards human skin cells (fibroblasts) with stress-inducedpremature senescence.

The next step of development could involve:

Studies of biological activity of novel hybrid compounds using a 3D cell model (synthetic skin model)

Exvivo studies in mammalian models.

Main features

40%

Unlimited

1 µM

slower cellular senescence

bioavailability

effective concentration

Newly Discovered Chemicals H3 & H5

H3 compound

potential to combat cell senescence by approximately 40% allowing cells to proliferate.

Created from resveratrol, a plant-derived substance and a nitroxyl radical (TEMPO) covalently linked by an esterbond.

Effective concentration of the substance at 1 µM - 100 times lower than effective concentration of resveratrol.

based on resveratrol

One-step synthesis

H5 Compound

Potential to combat cell senescence by approximately 40% allowing cells to proliferate.

Effective concentration of the substance at 0,5 µM - 10 times lower than effective concentration of curcumine.

based on curcumine

The synthesis yield 78%

Created from curcumine, a plant-derived substance and a nitroxyl radical (TEMPO) covalently linked by an esterbond

Experimental Data

All studies were performed towards human skin fibroblasts:

cytotoxic properties

biological activity

antioxidant activity

Formulation

Oily

Emulsion

Aqueous

Gel

A supporting statement for your value proposition to encourage customers to complete your CTA.

IP Protection

PCT application number:

During the International application

UPRP application number:

P.441664

PCT/PL2023/050049

Meet Our Scientists

The Litwinienko Group is a team of more than 10 scientists at the University of Warsaw dedicated to studies of the antioxidant activity of compounds.

Grzegorz Litwinienko

Professor and Litwinienko Group Leader

>75 publications

28 H-index

3510 citations

Adrian Konopko, Ph.D.

The main co-author

Postdoctoral researcher at Medical University of Warsaw,

The Regenerative Medicine Laboratory

Anna Bielak-Zmijewska - Associate professor member of Laboratory of Molecular Bases of Aging, PAS

>40 publications

28 H-index

1930 citations

Let's talk

Aleksandra Trzewik

Technology Broker at the University of Warsaw